Description
BPC-157 Overview and Research Summary
What Is BPC-157?
BPC-157, also known as Body Protection Compound-157, is a derivative of a protein found naturally in the human digestive tract. This protein plays a crucial role in protecting the gastrointestinal (GI) tract lining, promoting tissue healing, and facilitating blood vessel growth.
Synthetic BPC-157 is a pentadecapeptide consisting of 15 amino acids, isolated from the larger body protection compound protein. Research has shown that BPC-157 retains many of the healing properties of its parent molecule, particularly in areas such as:
- Wound healing
- Blood vessel growth
- The coagulation cascade
- Nitric oxide generation
- Immune system function
- Gene expression
- Hormone regulation, particularly in the gastrointestinal nervous system
BPC-157 Peptide Structure
- Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- Molecular Formula: C₆₂H₉₈N₁₅O₂₂
- Molecular Weight: 1419.556 g/mol
- PubChem CID: 108101
BPC-157 Peptide Research
- BPC-157 and Wound Healing
BPC-157 helps maintain the integrity of the mucosal barrier in the GI tract, which protects underlying tissues from gastric acid, bile, and other digestive compounds. It promotes wound healing by recruiting fibroblasts, which are critical for laying down extracellular matrix proteins like collagen, fibrin, and elastin. BPC-157 shows a dose-dependent effect on fibroblast proliferation and migration both in vitro and in vivo.
[Source: T. Huang et al., “Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro,” Drug Design, Development and Therapy, 2015.] - Vascular Growth and Collateralization
BPC-157 is a potent angiogenic factor that increases endothelial cell proliferation and growth, facilitating new blood vessel formation. Studies in animal models have shown that BPC-157 enhances collateral blood vessel growth, which can be particularly beneficial following ischemic injury in tissues such as the cardiovascular system, brain, and muscles.
[Source: F. Amic et al., “Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157,” World Journal of Gastroenterology, 2018.] - BPC-157 and Tendon Healing
BPC-157 has demonstrated promising results in animal models for healing injuries in tendons, ligaments, bones, and other connective tissues. It promotes fibroblast density and blood supply, which are essential for effective healing.
[Source: S. Seiwerth et al., “BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing,” Current Pharmaceutical Design, 2018.] - Antioxidant Properties
BPC-157 exhibits antioxidant properties by neutralizing oxidative stress markers like nitric oxide and malondialdehyde (MDA). This action reduces reactive oxygen species in the GI tract, further supporting its role in healing.
[Source: K. Škrlec et al., “Engineering recombinant Lactococcus lactis as a delivery vehicle for BPC-157 peptide with antioxidant activities,” Applied Microbiology and Biotechnology, 2018.] - BPC-157 and Drug Side Effects
BPC-157 can mitigate the side effects of certain drugs, such as NSAIDs and medications for psychiatric conditions, by protecting against gastrointestinal and cardiovascular side effects.
[Source: D. Strinic et al., “BPC 157 counteracts QTc prolongation induced by haloperidol, fluphenazine, clozapine, olanzapine, quetiapine, sulpiride, and metoclopramide in rats,” Life Sciences, 2017.]
Future BPC-157 Research
BPC-157 remains under investigation in various cell cultures and animal models, showing potential as both a therapeutic agent and a tool for exploring angiogenesis and wound healing processes. The peptide has demonstrated minimal side effects, moderate oral, and excellent subcutaneous bioavailability in animal studies. However, BPC-157 is currently available for educational and scientific research purposes only and is not intended for human consumption.
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